
Andrej Karpathy just open-sourced a 630-line script that lets AI agents run experiments, keep what works, and throw out what doesn't.
This 52 page detailed step-by-step guide covers everything from zero:
What AutoResearch actually is (and isn't)
Step-by-step setup on your own machine
Detailed application guide to real use cases:
Testing ads
Creating trading bots that iterate on themselves
YouTube thumbnails
Job postings
Discovery leads
How the "Karpathy Loop" works: editable asset, scalar metric, time-boxed cycle
How to write program.md instructions that actually produce good results
Whether you're a developer, a business owner, content creator, coach or just someone who wants to understand the most talked-about AI repo of 2026, this guide will get you there.